Abstract
Objective: B-type natriuretic peptide (BNP) participates in the coordination of endothelial regeneration/hypertrophy and the accompanying angiogenesis. Endothelial dysfunction is associated with increased mortality in patients on hypertension. The present study aimed to determine the relationship between serum N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) level and endothelial dysfunction in patients with hypertension Design and method: The present cross-sectional, single-center study included 90 hypertension patients. An electrochemiluminescence immunoassay was used to measure NT-pro-BNP levels. The endothelial function and vascular reactivity index (VRI) were measured using digital thermal monitoring (DTM) test (VENDYS). In this study, VRI < 1.0 was used as the poor vascular reactivity, 1.0 < VRI < 2.0 was used as the intermediate vascular reactivity, and VRI > 2.0 was used as the good vascular reactivity. Results: Eight hypertensive patients (8.9%) were categorized as poor vascular reactivity (VRI < 1.0), 39 hypertensive patients (43.3%) were categorized as intermediate vascular reactivity (1.0 < VRI < 2.0), and 43 hypertensive patients had good vascular reactivity. Older age (p = 0.012) and higher serum NT-pro-BNP level (p < 0.001) was associated with poor vascular reactivity. Advanced age (r = -0.221, p = 0.036) and logarithmically transformed serum level of NT-pro-BNP (log-NT-pro-BNP, r = -0.505, p < 0.001) was negatively associated with VRI values in hypertensive patients. After multivariable forward stepwise linear regression analysis noted that serum log-NT-pro-BNP level (adjusted R2 change = 0.246, p < 0.001) was significantly and independently associated with VRI values in hypertensive patients. Conclusions: Serum log-NT-pro-BNP levels were negative associated with VRI and associated with endothelial dysfunction in patients with hypertension.
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