Abstract
Serum nickel concentration in the different phases of the menstrual cycle and after use of a combined contraceptive pill (Anovlar) was determined by atomic absorption spectrophotometry. Twenty ovulating females had their serum nickel level measured on day 5 and on day 27 of their cycle. Forty females using Anovlar for 6 months and 40 females using it for more than 3 years had their serum nickel determined. The serum nickel concentration of the non-pill users was higher on day 5 (2.52 ± 0.46 ug/L) than on day 27 (2.21 ± 0.37 ug/Lp < 0.05). In long-term users, the serum nickel (0.98 ± 0.38 ug/L) was less than the short-term users (2.38 ± 0.35 ug/L, p < 0.01) and the non-users (p < 0.01). There was a negative correlation between the duration of pill use and the serum nickel level (r = −0.44, p < 0.01). The significance of the decreased serum nickel level with long-term pill use remains to be determined.
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