Abstract
Macrophage migration inhibitory activity has been detected in the sera of six of eight patients with hepatic dysfunction following transplantation (renal or hepatic) and immunosuppression. Three of these individuals had detectable Australia antigen. Serum MIF activity bore an interesting temporal relation to parameters of hepatic disease, especially serum glutamic oxaloacetic transminase (SGOT) levels. Elevations of serum MIF preceded elevations of SGOT by approximately 5–10 days. This suggests that cell-mediated immune mechanisms may have not been beneficial, but rather may have contributed to the underlying hepatic pathology.
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