Abstract
Abstract Objectives Coronavirus disease 2019 (COVID-19) is a kind of viral pneumonia which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). MicroRNAs (miRNA) are small non-coding RNAs consisting of 19–25 nucleotides and play a role in post-transcriptional gene regulation. We have focused on serum expression levels of microRNA (miRNA) a novel concept of in host–virus interactions. MicroRNA expression profiles were investigated in serum samples of COVID-19 patients. Materials and methods The samples were collected from 40 patients diagnosed with COVID-19 patients and from 10 healthy controls. Expression profile of 20 miRNAs were examined using a quantitative real-time polymerase chain reaction (qPCR). Results Statistically significant expression level differences (p < 0.05) were detected in nine miRNAs in COVID-19 patients and healthy controls. 7 miRNAs (hsa-let-7d, hsa-miR-17, hsa-miR-34b, hsa-miR-93, hsa-miR-200b, hsa-miR-200c, hsa-miR-223) expression levels were found to be significantly decreased and the expression levels of 2 miRNAs (hsa-miR-190a and hsa-miR-203) significantly increased respect to healthy controls. Conclusions We expect that a miRNA profile can be beneficial for the diagnosis of the COVID-19. Our result revealed that the increase in hsa-miR-190a level may be a prognostic factor related to the COVID-19 disease.
Highlights
In December 2019, unidentified cases of pneumonia occurred in Wuhan, China’s Hubei province
Our result revealed that the increase in hsa-miR-190a level may be a prognostic factor related to the COVID-19 disease
Our study is the first article demonstrating the serum miRNAs profile of patients diagnosed with SARS-CoV-2 and the healthy individuals
Summary
In December 2019, unidentified cases of pneumonia occurred in Wuhan, China’s Hubei province. The coronavirus-2019 (2019-nCoV) was identified as the cause of the cases [1]. Since the corona virus has a serious zoonotic potential, the first cases were associated with the Huanan seafood market where animal contact was possible [1]. Serious Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) caused pneumonia is contagious. The World Health Organization (WHO) named the disease as COVID-19 (CoronaVirus Disease 2019). On March 11, the WHO declared the COVID-19 outbreak as a pandemic [2]. The main symptoms of COVID-19 are fever, cough, fatigue, slight dyspnoea, sore throat, headache, conjunctivitis and gastrointestinal issues
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