Abstract
Serum MicroRNA-96 As a Potential Diagnostic Marker in Breast Cancer
Highlights
Breast cancer is the most common cause of cancer incidence in women; where it represents 11.7% of cancer cases worldwide, surpassing that of lung cancer [1]
MiR-96 belongs to the miR-183-96-182 cluster that was found to be located on human chromosome 7q32.2 within a 5-kb region [26]
Expressed miR-183-96-182 cluster was observed in different types of cancers, the exact role of this miRNA cluster remains unclear, where it can function as either tumor suppressor gene or an oncogene, depending on tumor stage, type, and location [2729]
Summary
Breast cancer is the most common cause of cancer incidence in women; where it represents 11.7% of cancer cases worldwide, surpassing that of lung cancer [1]. Altered microRNAs (miRNAs) expression has been observed in various human diseases including liver diseases [4], cardiovascular diseases [5], obesity, diabetes [6], and cancer [7]. This altered expression could be related to amplification and mutations in miRNAs, inhibition of miRNA processing, or epigenetic silencing [8]. A thorough investigation of the involvement of miRNAs in breast cancer development can provide better insights on tumorigenesis mechanisms and could help in the discovery of novel markers for the early detection of breast cancer
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