Abstract
Polycystic ovary syndrome (PCOS) is the most common endocrinopathies in women of reproductive age. The aim of the study was to determine the concentrations of some essential macro- and microelements in the body of women with PCOS. Taking into account the frequent combination of PCOS with inflammatory processes of genitals, it was decided to examine trace elements concentration in this category of women. Study includes 3 groups of women: 30 women with PCOS against the background of inflammatory diseases of pelvic organs (I group), 22 patients with PCOS without inflammatory processes of pelvic organs (II group) and 25 healthy women (III group). In all groups it was studies macro- and microelements concentration in blood: magnesium (Mg), copper (Cu), manganese (Mn), nickel (Ni), zinc (Zn), chromium (Cr), selenium (Se), vanadium (V). The study revealed increase zinc and nickel level, decrease manganese level in women with PCOS, that give grounds suppose their participation in the infringement of folliculogenesis and ovulation due to their properties to intensification of the lipids peroxide oxidation and reduction activity of antioxidant system, injuries cell membranes and mitochondria, gap DNA molecules and to disturb transcription processes. More high zinc and nickel concentrations in patients with PCOS in the background of inflammatory process indicates on possible inflammation role in disorders development, because proinflammatory cytokines (IL-1, IL-6, IL-18, TNF-α) leads to the zinc accumulation and elevated nickel concentrations can induce inflammation and inhibit the functional activity of macrophages and natural killer cells, setting the conditions for chronic inflammation. Level study of trace elements (zinc, nickel and manganese) may be recommended for women with PCOS and with inflammatory diseases of pelvic organs and control their administration in complex multivitamin preparations.
Highlights
MD, professor, corresponding member of NAMS of Ukraine, deputy director for research work, Chief of the Polycystic ovary syndrome (PCOS) is a common disease with incidence of 5–10% among women of Endocrine Gynecology Department, fertile age [1]
MATERIAL AND METHODS OF THE STUDY Three groups of women were included into the study: 30 women with polycystic ovarian syndrome associated with pelvic inflammatory disease (І group), 22 patients with polycystic ovarian syndrome without pelvic inflammatory disease (ІІ group), and 25 healthy women (IІІ group)
We found the single work of Chinese investigators which revealed increase in serum nickel levels in PCOS women [7]
Summary
MD, professor, corresponding member of NAMS of Ukraine, deputy director for research work, Chief of the Polycystic ovary syndrome (PCOS) is a common disease with incidence of 5–10% among women of Endocrine Gynecology Department, fertile age [1]. Previously thought that PCOS is a disease of women of fertile age only. RESEARCH OBJECTIVE human body contains 3% of metals [7]. Their content varies from a couple of micrograms. Though 69 metals are preclinic No 3, Advisory and Diagnostic sented in cells in different amounts, all of them play
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