Serum Magnesium Level In Diabetic And Osteoporosis-Risk Thai Female Subjects

Abstract

Osteoporosis is an important physiological change in elderly post-menopause female subjects. It can induce a lot of complications such as hip fracture. Similar to serum calcium and phosphorus, serum magnesium is decrease in the osteoporosis subjects. In the present day, a number of risk factor for osteoporosis (such as diabetes mellitus low BMI, high alcohol consumption and etc.) are mentioned. In this study, evaluation of serum magnesium levels among osteoporosis-risk Thai pre-menopause subjects comparing to low risk matched control group was performed. A total of 77 female subjects, 15 low risk control subjects and 62 osteoporosis-risk subjects (40 subjects with uncomplicated diabetes mellitus and 22 subjects with other risks) were included into this study. Serum magnesium determination by AAS method was performed. Average serum magnesium level in low risk control group and osteoporosis-risk group were 2.18 ± 0.27 mg/dl and 2.17 ± 0.56 mg/dl (2.12 ± 0.62 mg/dl for diabetic subjects and 2.25 ± 0.26 mg/dl for other risk subjects), respectively. There was no significant difference between low risk and osteoporosis-risk subjects (P > 0.05). However, a significant between low risk and osteoporosis-risk subjects in diabetic group (P < 0.05) was determined in our study. Conclusion that serum magnesium level cannot be used as general osteoporosis marker for pre-menopausal subjects was set.