SERUM MAGNESIUM CONCENTRATION IS REVERSELY ASSOCIATED WITH ARTERIAL STIFFNESS IN YOUNG ADULTS WITH HYPERTENSION

Abstract

Objective: Magensium deficeincy is known as a risk factor for cardiovascular disease. However, the data on it's role in arterial stiffness developement is controversial. Our aim was to investigate the association of serum magnesium levels with arterial stiffness in young hypertensive patients. Design and method: We included 94 adults 18–45 years old with masked and sustained hypertension verified with 24-hours ambulatory blood pressure monitoring (ABPM). None of them were on blood pressure (BP) lowering treatment. We performed routine clinical investigation including anthropometry, biochemical blood assay, office BP measurement and ABPM. Atrerial stiffness was estimated with applanation tonometry and cardio-ankle vascular index (CAVI) measurement. To investigate the relationship between serum magnesium concentration and other variables we used Spearman's rank correlation coefficient. Results: Median age was 23[21–25] years, 79% were males, median body mass index - 24.9 [22.3;28.7]. Median serum magnesium level was 0,9 [0,84;0,94]. No significant associations were found for magnesium concentration and BP characteristics, neigher office, nor 24-hours. Pulse wave velocity was reversely associated with serum magensium level: (-0,184), p = 0,013. Magnesium concentration had also reverse significant correlation with CAVI (-0,300), p < 0,001. These findings were independent of blood pressure levels, body mass index and insulin resistance. Conclusions: Serum magnesium concentration is reversely associated with pulse wave velocity and cardio-ankle vascular index in young patients with hypertension.