Abstract
Background: Previous studies found that low blood magnesium increases the risk of several diseases such as cardiovascular diseases (CVD), diabetes, and hypertension. These ailments are associated with declined cognitive function.Objective: We aimed to examine the association between serum magnesium and cognitive function among Qatari adults. In addition, we assessed the interaction relation between low serum magnesium, hypertension, and diabetes in relation to cognitive function.Method: Data from 1,000 Qatari participants aged ≥20 years old who participated in the Qatar Biobank (QBB) Study were analyzed. Serum magnesium was measured by an automated calorimetric method and suboptimal magnesium was characterized by <0.85 mmol/l. Cognitive function was determined by measuring the mean reaction time (MRT) based on a computer-based, self-administered test. Multivariable linear regression was used to examine the relation between serum magnesium concentrations and cognitive function.Results: The prevalence of suboptimal magnesium was 57.1%. Across the four quartiles of serum magnesium from the lowest to the highest, the regression coefficients (95% CI) for MRT were 0 (reference), −17.8, −18.3, and −31.9 (95% CI 2.4–3.1; p for trend 0.05). The presence of hypertension and diabetes significantly increased the MRT. Women with suboptimal magnesium and hypertension had the highest MRT.Conclusion: The prevalence of suboptimal magnesium is high in Qatar. There was a direct association between serum magnesium and cognitive function. Low magnesium concentrations were associated with a longer MRT.
Highlights
Dementia is a major neurocognitive disorder characterized by a decline in memory, problemsolving, language, and other cognitive skills (Hugo and Ganguli, 2014)
Among women with suboptimal magnesium, there. In this cross-sectional study, serum magnesium concentration was inversely associated with Mean reaction time (MRT)
There was an interaction between gender, diabetes, and low serum magnesium. Those with hypertension and low serum magnesium concentrations, the MRT was longer in women but not in men
Summary
Dementia is a major neurocognitive disorder characterized by a decline in memory, problemsolving, language, and other cognitive skills (Hugo and Ganguli, 2014). Most of the existing studies found a beneficial effect of fish, nuts, and fresh vegetable intake on cognition (Scarmeas et al, 2018). The association between individual nutrients intake and cognition is inconclusive (Scarmeas et al, 2018). Previous studies found that low blood magnesium increases the risk of several diseases such as cardiovascular diseases (CVD), diabetes, and hypertension. These ailments are associated with declined cognitive function
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