Abstract
Magnesium (Mg) status has recently drawn close attention in chronic kidney disease and in kidney transplant recipients. This review aims to evaluate the body of evidence linking hypomagnesemia to clinical consequences in these specific populations. After a brief summary of the main mechanisms involved in Mg regulation and of Mg status in end-stage renal disease, the review focuses on the relationship between hypomagnesemia and cardiovascular risk in kidney transplant recipients. A body of evidence in recent studies points to a negative impact of hypomagnesemia on post-transplant diabetes mellitus (PTDM) and cardiovascular risk, which currently represent the main threat for morbidity and mortality in kidney transplantation. Deleterious biological mechanisms induced by hypomagnesemia are also discussed. While data analysis enables us to conclude that hypomagnesemia is linked to the development of PTDM, studies prospectively evaluating the impact of hypomagnesemia correction after kidney transplantation are still lacking and needed.
Highlights
Magnesium (Mg) status has recently drawn close attention in chronic kidney disease and in kidney transplant recipients
Dialysate Mg concentration has a significant impact on Mg balance in hemodialysis (HD) or peritoneal dialysis (PD) patients
Serum Mg concentration appeared as an independent risk factor of vascular calcification
Summary
Anne-Sophie Garnier 1,2 ID , Agnès Duveau 1,2 , Martin Planchais 1,2 , Jean-François Subra 1,2,3 , Johnny Sayegh 1,2 and Jean-François Augusto 1,2,3, * ID. CRCINA, INSERM, Université de Nantes, Université d’Angers, LabEx IGO Immunotherapy, Graft, Oncology, 44007 Angers, France
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