Abstract
Bloodstream form Trypanosoma brucei brucei IL3201 and IL3202, derived from two different serodemes, were adapted to grow in a semi-defined medium under axenic culture conditions. The organisms required low- or high-density lipoproteins, isolated from foetal bovine serum (FBS) in addition to components of lipoprotein-depleted serum, to multiply in vitro. Low- and high-density lipoproteins, isolated from a number of different species, were equally efficient at supporting in vitro growth of the parasites in medium supplemented with lipoprotein-depleted FBS. Chylomicrons and very-low-density lipoproteins did not support multiplication of the T. b. brucei and did not influence the capacity of low- or high-density lipoproteins to support parasite multiplication. Removal of the lipoprotein-lipids abrogated the capacity of low- or high-density lipoproteins to support T. b. brucei multiplication.
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