Serum lipid profiles, lipid ratios and Chronic Kidney Disease in a Chinese population.

Liying Zhang,Zhiyong Yuan,Hequn Zou,Xinyu Liu,Shanying Chen,Xiaofei Shao,Wu Chen,Yan Liang

doi:10.3390/ijerph110807622

Abstract

Aim: To examine the association of serum lipids, lipid ratios with Chronic Kidney Disease (CKD) in a Chinese population. Methods: Data were drawn from a cross-sectional survey in China. CKD was defined as estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73m2 or albuminuria-to-creatinine ratio (ACR) > 30 mg/g. Multivariable logistic regressions and multivariate regression models were used. Serum lipids and lipid ratios included total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio and LDL-C/HDL-C ratio. Results: In men, only logarithm-transformed (log) TG was associated with CKD. The odds ratio (every SD increment) was 1.39 (95% CI 1.03–1.87, P = 0.03). In women, none of the serum lipids and lipid ratios was associated with CKD. Using multivariate regression models, it was shown that log TG and log TG/HDL-C were negatively correlated with eGFR (P < 0.05) in men and LDL-C and log LDL-C/HDL-C ratio were correlated with ACR in men. In female subjects, serum TC, log TG, log TG/HDL-C and log TC/HDL-C were negatively correlated with eGFR (P < 0.05). All of serum lipid profiles and lipid related ratio were not correlated with ACR in women. Conclusion: Serum TG is the only suitable predictor for CKD in men. However, in women, none of serum lipids and lipid ratio can be used as a predictor for CKD. Log TG and log TG/HDL-C are negatively correlated with eGFR in both genders.

Highlights

It is well recognized that serum lipids are linked to atherosclerotic diseases [1]
Women had a higher level of estimated glomerular filtration rate (eGFR) than men, but there was no significant difference on prevalence of Chronic Kidney Disease (CKD) between men and women
Among serum lipids profiles and lipid ratios, only serum TG is a suitable predictor for CKD in men and the association is independent of other potential confounders

Summary

Introduction

It is well recognized that serum lipids are linked to atherosclerotic diseases [1]. Chronic kidney disease (CKD) shares some common risk factors, such as hypertension and diabetes, with cardiovascular diseases. Serum lipids might be independent risk factors for CKD. The results of previous studies are inconsistent [2,3,4,5,6]. A study by Kurella et al [2] indicated that each component of metabolic syndrome including hypertriglyceridemia and low high density lipoprotein cholesterol (HDL-C) is an independent risk factor of developing CKD. Previous studies based on Korean populations indicated that triglyceride (TG)/HDL-C ratio is independently associated with CKD [3,4]

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Results

Conclusion