SERUM LIPID PROFILE

Abstract

… Objectives: This study was conducted to determine serum lipid profile in childrenof premature coronary heart disease patients and compare results between children havingparents with one, two or three risk factors. Study Design: A cross sectional comparative study.Patients and Methods: Ninety seven (97) subjects having parents with one risk factor, sixty three(63) subjects having parents with two risk factors and sixty five (65) subjects having parents withthree risk factors were selected from Punjab Institute of Cardiology Lahore. Fifty (50) age and sexmatched subjects of parents without a history of coronary heart disease were also selected. Theserum total cholesterol, serum triglycerides, serum low density lipoprotein cholesterol andserum high density lipoprotein cholesterol was performed and results were compared. Results:Offsprings of parents having more number of risk factors had statistically significantly high totalcholesterol and low density lipoprotein cholesterol as compared with offsprings of parentshaving one risk factor. Triglycerides and high density lipoprotein cholesterol of offsprings ofparents having one, two, three or more than three risk factors were comparable. Offsprings ofparents having premature coronary heart disease (CHD) had abnormal lipid levels as comparedwith control group. Conclusions: Coronary heart disease risk factors are significant regardingabnormal lipid levels. Offsprings of premature CHD patients are prone to develop CHD ascompared to normal control group. Genetic predisposition seems to be important indevelopment of CHD.