Serum Lipid Profile status of Type 2 Diabetic Patients in the cross section population in Dhaka City of Bangladesh

Ak Azad,Bidan Chandra Sarkar,Hasi Rani Saha,Niranjan Kumar Sana,Subhagata Choudhury

doi:10.3329/bjms.v11i2.11479

Abstract

Objectives: Serum lipid profile viz the level of total cholesterol (TC), Triglyceride (TG), HDL-cholesterol and LDL-cholesterol of type2 diabetic patients have been studied and compares them with levels of control subjects. Results: The mean value of the TG level for male diabetics was higher than that for the female diabetics and the mean values of TC, HDL-C and LDL-C were not found significantly different between male and female diabetics. Hyperlipidemia has a documented causative relation with CAD, but the major risk associated with diabetes may be due to the associated hyperlipidemia. The study revealed that dyslipidemia is very common in type2 diabetics and the most common abnormality observed was increased serum triglyceride levels (58%). The next common abnormality was decreased serum high-density lipoprotein cholesterol (HDL-C) levels and increased serum low-density lipoprotein cholesterol (LDL-C) levels. A high total serum cholesterol levels was found in 41% patients. 39% of the patients examined were overweight, and 7% were overtly obese. Conclusion: Thus, the study clearly shows the relationship between type2 diabetes and hyperlipidemia, which may influence the mechanism by which type2 diabetes is associated with increased CAD risk. DOI: http://dx.doi.org/10.3329/bjms.v11i2.11479 Bangladesh Journal of Medical Science Vol. 11 No. 02 April 2012: 121-125

Highlights

Diabetes is one of our greatest public health problems, primarily because of the dramatic increase in type[2] diabetes, known as age-related diabetes, which represents a global threat to human health
Lipid abnormalities and diabetes have been recognized as independent risk factors for coronary artery disease (CAD) events and atherosclerosis
Evidence supports an independent link between low levels of high-density lipoprotein cholesterol (HDL-C)[2] and high levels of triglycerides (TG) 3,4 and atherosclerosis and CAD

Summary

Introduction

Diabetes is one of our greatest public health problems, primarily because of the dramatic increase in type[2] diabetes, known as age-related diabetes, which represents a global threat to human health. Lipid abnormalities and diabetes have been recognized as independent risk factors for coronary artery disease (CAD) events and atherosclerosis. The link between elevated low-density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD) is firmly established. Evidence supports an independent link between low levels of high-density lipoprotein cholesterol (HDL-C)[2] and high levels of triglycerides (TG) 3,4 and atherosclerosis and CAD. CAD and type[2] diabetes may be significantly linked by the presence of dyslipidemia which is characterized by low HDL-C with high LDL-C and TG. Such a pattern of dyslipidemia has been frequently observed in patients with type[2] diabetes. A study has shown that the prevalence of hyperlipidemia in type[2] diabetes can be as high as

Objectives

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Conclusion