Abstract
BackgroundResearch on dyslipidemia during pregnancy in women with gestational diabetes mellitus (GDM) has rarely been conducted in Asia. The present study aimed to evaluate maternal mid-trimester lipid profile in relation to GDM and clinical outcomes in these high-risk populations.MethodsThe medical records of 632 pregnant women in the second trimester were retrospectively analyzed. Maternal fasting serum lipids were assayed for total cholesterol (TC), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), apolipoprotein A1 (Apo A1) and Apo B concentrations during the second trimester. The atherogenic index of plasma (AIP) was calculated as log (TG/HDL). The clinical outcomes were collected by evaluating delivery mode, postpartum hemorrhage, prematurity, macrosomia, birth weight, body length and neonatal Apgar 5 min score.ResultsLevels of TG and AIP were elevated while decreased HDL-C was observed in women with GDM compared with that of the control group. Significant differences were observed in gestational weeks at birth, cesarean section, postpartum hemorrhage, birth weight, body length, prematurity and macrosomia between the two groups. Compared with women with hyperlipidemia, the incidence of GDM and cesarean section was lower in normal lipid group. Women in the hyperlipidemia group had smaller gestational weeks at birth than those in the control group. According to the logistic regression analysis, each unit elevation in AIP increased the risk of GDM by 18.48 times (OR = 18.48, CI: 2.38–143.22). Besides, age (OR = 1.11, CI: 1.06–1.16) and pre-pregnancy BMI (OR = 1.15, CI: 1.07–1.24) were the risk factors of GDM.ConclusionsThese findings suggested that reasonable lipid control in the second trimester might reduce the incidence of GDM and be a potential strategy for improving clinical outcomes in these high-risk women.
Highlights
Research on dyslipidemia during pregnancy in women with gestational diabetes mellitus (GDM) has rarely been conducted in Asia
The prepregnancy body mass index (BMI) was significantly higher in the GDM group than that in the control group (22.86 ± 1.97 vs. 23.52 ± 2.42 kg/m2, P < 0.001)
Previous research found that diabetic patients had statistically significantly higher levels of atherogenic index of plasma (AIP) than the control group [31,32,33]. In concordance with these reports, our results showed that the level of AIP among women with GDM was higher than the non-GDM population
Summary
Research on dyslipidemia during pregnancy in women with gestational diabetes mellitus (GDM) has rarely been conducted in Asia. Maternal energy metabolism in the second half of pregnancy is directed toward lipolysis, which indicates a physiological adaptation of mothers to maintain stable fuel supplementation to the fetus [1, 2]. Increased lipidemia occurs in early pregnancy, with a more pronounced elevation by the second and third trimesters [2,3,4]. Gestational diabetes mellitus (GDM) is a common metabolic complication in pregnant women and affects up to 22% of pregnancies [5]. Pregnant persons with GDM are at increased risk for maternal and neonatal complications, including cesarean delivery, postpartum hemorrhage, preterm birth, macrosomia, small for gestational age (SGA) and low Apgar score [6,7,8]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
