Abstract
BackgroundCardiovascular and cerebrovascular diseases have become leading causes of death in China as the economy develop and lifestyles change. This study aimed to estimate the relationship of the age, gender, and glucose metabolism with the serum lipid and lipoprotein levels of middle-aged and elderly Chinese men and women in Shandong Province.MethodsWe conducted a cross-sectional study in Shandong Province that included 10,028 adults aged ≥40 years. Fasting serum total, low-density lipoprotein (LDL), high-density lipoprotein (HDL) cholesterol and triglycerides were measured by standard methods.ResultsThe estimates of total, LDL, and HDL cholesterol and triglycerides were as follows: 5.35, 3.18, 1.51, and 1.34 mmol/L in the middle-aged and elderly Chinese adult population; 5.14, 3.08, 1.42, and 1.33 mmol/L in male subjects; 5.46, 3.24, 1.56, and 1.34 mmol/L in females; 5.27, 3.11, 1.54, and 1.24 mmol/L in the normal glucose tolerance population, 5.49, 3.27, 1.50, and 1.41 mmol/L in the population with pre-diabetes, and 5.39, 3.23, 1.43, and 1.58 mmol/L in the population with diabetes, respectively. Moreover, 36.92 and 19.10% of the adults had borderline-high and high total cholesterol. The population estimates for borderline-high, high LDL and low HDL cholesterol levels were 25.24, 13.39, and 5.64%, respectively. Meanwhile, borderline high and high triglyceride levels accounted for 16.7 and 17.47% of the population, respectively.ConclusionsSerum total and LDL cholesterol levels were high in the ≥40 years old population of Shandong Province. Age, gender, glucose metabolism status, body mass index (BMI) and glycosylated hemoglobin (HbA1c) can affect serum lipid and lipoprotein levels.
Highlights
Cardiovascular and cerebrovascular diseases have become leading causes of death in China as the economy develop and lifestyles change
With the economic developments and adverse changes in lifestyle, cardiovascular and cerebrovascular diseases have become the important cause of death in China [1, 2]. 42.8% of deaths in adults aged ≥40 years were estimated to be attributable to heart disease and stroke in 1991–2000 in a Chinese national prospective cohort study [2]
Our study shows that mean levels of total and low-density lipoprotein (LDL) cholesterol and triglycerides are considerably higher than the previous report in the general Chinese adult population [16,17,18,19]
Summary
Cardiovascular and cerebrovascular diseases have become leading causes of death in China as the economy develop and lifestyles change. This study aimed to estimate the relationship of the age, gender, and glucose metabolism with the serum lipid and lipoprotein levels of middle-aged and elderly Chinese men and women in Shandong Province. With the economic developments and adverse changes in lifestyle (such as a decreased physical activity and high-calorie food intake), cardiovascular and cerebrovascular diseases have become the important cause of death in China [1, 2]. 42.8% of deaths in adults aged ≥40 years were estimated to be attributable to heart disease and stroke in 1991–2000 in a Chinese national prospective cohort study [2]. Elevated serum lipids are one of the most important modifiable risk factors for cardiovascular
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