SERUM LEVELS OF VITAMIN D AND INTERLEUKIN – 17A IN ACNE VULGARIS PATIENTS

Abstract

Background: Vitamin D plays an important role in the human immune system, and its deficiency has been implicated in various skin diseases, including atopic dermatitis and psoriasis. Acne is a common inflammatory skin disease; however, the association with vitamin D remains unclear. Additionally, the T helper 17 pathway may contribute to the inflammatory response in acne. This study evaluated serum vitamin D and IL-17A levels in acne patients, simultaneously analyzed the relationship between serum vitamin D and IL-17A levels with severity of acne, in order to investigate the possible role of vitamin D and IL-17A in the disease pathogenesis.Objectives: To compare serum IL-17A and vitamin D levels in acne patients with non-affected individuals; to analyze the relationship between serum IL-17A and vitamin D levels with the severity of acne; to discover the relationship between serum IL-17A and vitamin D levels. Method: Analytical cross-sectional study in 35 acne patients and 27 healthy peopleResults: Serum vitamin D levels were significantly lower in acne patients (p = 0.01). Vitamin D deficiency was detected in 42.8% of patients with acne, but in only 11.1% of thehealthy people. The correlation between serum levels of vitamin D and IL-17A with severity of acne were significant (p < 0.05).Conclusion: Vitamin D and IL-17A may have a possible role in active acne vulgaris. Vitamin D supplementation as a treatment option may be considered for further studie