Serum Levels of Tumor Associated Trypsin Inhibitor (TATT) and Glomerular Filtration Rate

Abstract

TATI (tumor associated trypsin inhibitor) is a low molecular weight protein employed as a tumor marker. To evaluate the role of the kidney in the clearance of TATI, we studied the rat kidney uptake of 125I-TATI. Total body scan demonstrated a high radioactivity in the kidneys of the rats and none in other organs. The relationship between serum TATI and glomerular filtration rate (GFR) was studied in man. For comparison serum β2-microglobulin (β2M) arid plasma creatinine were also determined The decrease in GFR was accompanied by an increase in the other parameters. Serum TATI increased in patients with renal failure (GFR <20 mL/min) 12.4 times with respect to subjects with normal renal function (p <0.001, non-parametric Mann-Whitney test), β2M increased 7.6 times (p <0.001) and creatinine 4.7 times (p <0. 001). The increase in TATI is statistically significant already in patients with GFR 60–40 mL/min (p <0.005). These results suggest that TATI is handled by the kidney. It is a sensitive marker of reduction in renal function.