Abstract
IntroductionMortality and morbidity related to traumatic brain injuries still remain high in patients. Many authors reported the importance of Selenium in maintaining the integrity of brain functions. This fact is supported by clinical evidence that therapy with selenium supplementation could help patients suffering from brain disorders like neurodegenerative diseases. The aim of our study was to assess the relationship between Selenium concentration in serum and evolution of comatose patients with severe traumatic brain injury, in the first week of admission, and the correlation between selenium and C-reactive protein.MethodsThis case-control study was conducted with 64 comatose patients with TBI, in the Department of Anesthesiology and Reanimation, IbnSina University Hospital and Hospital of specialties in Rabat-Morocco, and healthy volunteers recruited in Blood transfusion center of Rabat. Blood sampling was collected from TBI patients, in the first week (3h after admission and each 48h during one week), and from healthy volunteers one time. Concentration of Se in serum was determined by electrochemical atomic absorption spectrometry. Statistical analysis was performed using Statistical software (SPSS) and the cases and controls were compared using the Mann-Whitney U test. A P-value < 0.05 was considered to be statistically significant.ResultsComparison selenium concentration in the first day (D0), third day (D2) and fifth day according to the death and survival statue in patients did not show statistical significance (p > 0.05). Selenium concentration of D0 in patients and Selenium concentration in control group also did not show statistical significance (p > 0.05). Similarly, we did not report a correlation between selenium and C-reactive protein.ConclusionAccording to our data selenium and CRP may not play a role in progression of coma state in patients with severe traumatic brain injury.
Highlights
Mortality and morbidity related to traumatic brain injuries still remain high in patients
Study design: This case-control study was conducted with 64 comatose patients with traumatic brain injury (TBI) identified as cases and healthy volunteers identified as controls recruited in Blood transfusion center of Rabat
Our data has shown that CRT concentration in D0 and third day (D2) was higher in men
Summary
Mortality and morbidity related to traumatic brain injuries still remain high in patients. Serum CRP level is strongly correlated to severity of the brain injury in patients [10] This protein is known as a sensitive biomarker of systemic inflammation in response to infection, trauma, surgery, burns, tissue infarction, advanced cancer, and chronic inflammatory conditions [11, 12]. The aim of our study was to assess the relationship between Selenium concentration in serum and evolution of comatose patients with severe traumatic brain injury, within the first week of admission, and the correlation between selenium and C-reactive protein
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