Abstract
Serum polyamines were determined by Samejima's method.Total putrescine, cadaverine and spermidine in healthy adults were 0.29±0.08, 0.11 ± 0.08. and 0.43 ± 0.15 nmoles/ml. respectively. Spermidine was not detected in the serum by this method. About half of total polyamines existed in free form in the serum. No significant elevation of serum polyamines was observed in chronic hepatitis and liver cirrhosis. Increased serum putrescine was observed in some cases of malignancies, such as hepatomas (0.76 nmoles/ml. 0.62 nmoles/ml), pharyngeal carcinoma (0.66 nmoles/ml), peritonitis carcinoma (0.60 nmoles/ml) and colon carcinoma (0.45 nmoles/ml). Determination of serum polyamines. especially of putrescine, may provide a potential indicator in some cases of malignancy.
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