Abstract
BackgroundPeriostin is induced by IL-13 and has been studied as a biomarker of asthma. The present study explored the relationship between serum levels of periostin and exercise-induced bronchoconstriction (EIB) in asthmatic children. MethodsThe study population consisted of 86 children 6–15 years old divided into an asthmatic group (n = 56) and healthy controls (n = 30). We measured the levels of periostin in serum and performed pulmonary function tests including baseline measurements, post-bronchodilator inhalation tests, exercise bronchial provocation tests (BPTs), and mannitol BPTs. ResultsThe 56 asthmatic children were divided into four groups: asthmatics with positive exercise BPT and positive mannitol BPT (n = 30), asthmatics with positive exercise BPT but negative mannitol BPT (n = 7), asthmatics with negative exercise BPT but positive mannitol BPT (n = 10), and asthmatics with negative exercise BPT and negative mannitol BPT (n = 9). Serum levels of periostin in asthmatic children with both positive exercise and mannitol BPT were significantly greater than those in asthmatic children with both negative exercise and mannitol BPT (95.0 [75.0–104.0] vs. 79.0 [68.0–82.5] ng/mL, P = 0.008) and controls (74.0 [69.75–80.0] ng/mL, P < 0.001). Periostin levels were significantly correlated with both the maximum decrease in %FEV1 and mannitol PD15 value. ConclusionSerum levels of periostin in asthmatic children with both positive exercise and mannitol BPT were significantly greater than those in asthmatic children with both negative exercise and mannitol BPT and also greater than in healthy controls.
Highlights
Periostin is induced by IL-13 and has been studied as a biomarker of asthma
As we reported previously that serum levels of periostin are associated with airway hyperresponsiveness (AHR) to methacholine and mannitol,[11] we hypothesized that periostin may be correlated with AHR induced by exercise in asthmatic children
The 56 asthmatic children were divided into four groups: asthmatics with positive exercise bronchial provocation tests (BPTs) and positive mannitol BPT (n 1⁄4 30), asthmatics with positive exercise BPT but negative mannitol BPT (n 1⁄4 7), asthmatics with negative exercise BPT but positive mannitol BPT (n 1⁄4 10), and asthmatics with negative exercise BPT and negative mannitol BPT (n 1⁄4 9)
Summary
The present study explored the relationship between serum levels of periostin and exercise-induced bronchoconstriction (EIB) in asthmatic children. Serum levels of periostin in asthmatic children with both positive exercise and mannitol BPT were significantly greater than those in asthmatic children with both negative exercise and mannitol BPT (95.0 [75.0–104.0] vs 79.0 [68.0–82.5] ng/mL, P 1⁄4 0.008) and controls (74.0 [69.75–80.0] ng/ mL, P < 0.001). Conclusion: Serum levels of periostin in asthmatic children with both positive exercise and mannitol BPT were significantly greater than those in asthmatic children with both negative exercise and mannitol BPT and greater than in healthy controls. Periostin is induced by IL-13 and can induce proinflammatory cytokines, including thymic stromal lymphopoietin (TSLP).[8,9] Recently, it was suggested that TSLP in combination with IL-33 increases mast cell formation of eicosanoids, which are important in patients with EIB.[10]
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