Serum Levels of PDGF, EGF, and sFlt-1 in Patients with Polycystic Ovary Syndrome and Their Predictive Effects on Pregnancy Outcomes.

Jiefan Gao,Donghui Wang,Dan Zhang,Yangyang Song,Xiao Huang

doi:10.1155/2021/7118464

Abstract

Polycystic ovary syndrome (PCOS) is a neuroendocrine disease with complex etiology characterized by infrequent menstruation, follicular developmental disorders, insulin resistance, and hyperandrogenism. PCOS patients often suffer from anovulatory infertility, and even after successful pregnancy promotion, spontaneous abortion is easy to occur. At present, PCOS is mainly diagnosed by auxiliary examinations such as sex hormones and B ultrasonography, and there is a lack of specific serological markers for the diagnosis of diseases. Similarly, there is a lack of effective evaluation methods for the risk of abortion in PCOS patients. Therefore, it is extremely important to explore the factors that affect the occurrence of abortion in PCOS patients and to find specific indicators that can guide the pregnancy outcome of PCOS patients. The purpose of this study was to investigate the serum levels of platelet-derived growth factor (PDGF), epidermal growth factor (EGF), and soluble fms-like tyrosine kinase-1 (sFlt-1) in PCOS patients and analyze their predictive effects on the pregnancy outcomes of PCOS patients. The results showed that serum PDGF, EGF, and sFlt-1 levels were secreted abnormally in PCOS patients with abortion and were closely related to the pregnancy outcome of PCOS patients. The combination of the three levels has the highest value in predicting the pregnancy outcome of PCOS patients, which is worth promoting.

Highlights

Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women of childbearing age, characterized by increased androgen and persistent anovulation.e incidence of PCOS accounts for 5%–21% of infertile women and 75%–80% of anovulatory women [1, 2]
Single factor analysis and multiple factor analysis were used to analyze the related factors affecting the pregnancy outcome of the patients. e Spearman correlation was used to analyze the correlation between serum Platelet-derived growth factor (PDGF), Epidermal growth factor (EGF), and Soluble fms-like tyrosine kinase-1 (sFlt-1) levels of patients and pregnancy outcomes. en, the ROC curve was used to analyze the predictive value of serum PDGF, EGF, and sFlt-1 levels on abortion in PCOS patients
Multivariate logistic analysis showed that age, body mass index (BMI), diabetes, hypertension, endometrial thickness, and serum PDGF, EGF, and sFlt-1 levels were all independent factors affecting the pregnancy outcome of PCOS patients (P < 0.05), as shown in Tables 2 and 3

Summary

Introduction

Polycystic ovary syndrome (PCOS) is one of the common endocrine disorders in women of childbearing age, characterized by increased androgen and persistent anovulation.e incidence of PCOS accounts for 5%–21% of infertile women and 75%–80% of anovulatory women [1, 2]. Epidermal growth factor (EGF) is a single-chain polypeptide consisting of 53 amino acids which is mainly produced in glandular, pancreatic, thyroid, liver, oocyte, blastocyst, and other tissues. It acts in the fallopian tube and uterus through paracrine to regulate the functional activities of the ovary, such as cell proliferation and differentiation, and steroid hormone production. It may be involved in the regulation of aromatase activity in ovarian granulosa cells, which is related to the occurrence of PCOS [9, 10]. Soluble fms-like tyrosine kinase-1 (sFlt-1) is a clipped form of fmslike tyrosine kinase-1 (Flt-1) that retains the ligand-binding

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Conclusion