Abstract
BackgroundIn the present study, we sought to generate hypotheses regarding the associations of serum levels of interleukin (IL)-17, adiponectin, and resistin with magnetic resonance imaging-measured infrapatellar fat pad (IPFP) size and signal intensity alterations in patients with knee osteoarthritis (OA).MethodsA total of 170 subjects with symptomatic knee OA (mean age 55.4 years, range 34–74, 88.2 % females) were included. IPFP volume was measured on T1-weighted spoiled gradient-recalled acquisition in the steady state images and was computed by using a software program. IPFP high signal intensity (grades 0–3) was assessed on T2-weighted fast spin echo images. Serum IL-17, adiponectin, and resistin levels were measured using an enzyme-linked immunosorbent assay.ResultsIn multivariable analyses, serum IL-17 was negatively associated with IPFP volume (β = −0.185, 95 % CI −0.337 to −0.034) but positively associated with the severity of IPFP signal intensity alteration (OR 1.23, 95 % CI 1.06–1.42) after adjustment for age, sex, weight, and height. Serum adiponectin was positively associated with IPFP volume (β = 0.016, 95 % CI 0.001–0.032) but negatively associated with IPFP signal intensity alteration (OR 0.99, 95 % CI 0.98–1.00) after adjustment for covariates. Resistin was positively associated with IPFP signal intensity alteration (OR 1.13, 95 % CI 1.04–1.23) but not with IPFP volume. The significant associations of adiponectin or resistin disappeared after further adjustment for IL-17; in contrast, the significant associations of IL-17 remained after further adjustment for adiponectin.ConclusionsWhile serum IL-17 and resistin were associated with reduced IPFP volume and/or increased abnormal signal intensity alteration, serum adiponectin had opposite associations that were largely through IL-17. These findings suggest that serum adipocytokines may have a role to play in IPFP changes of knee OA.
Highlights
In the present study, we sought to generate hypotheses regarding the associations of serum levels of interleukin (IL)-17, adiponectin, and resistin with magnetic resonance imaging-measured infrapatellar fat pad (IPFP) size and signal intensity alterations in patients with knee osteoarthritis (OA)
Patients with higher and lower levels of IL-17 were similar in terms of sex, Body mass index (BMI), height, weight, knee OA, IPFP signal intensity alteration, IPFP volume, and resistin level
Serum levels of IL-17 were significantly associated with serum levels of adiponectin (r = −0.234, p = 0.002) and resistin (r = 0.165, p = 0.032)
Summary
We sought to generate hypotheses regarding the associations of serum levels of interleukin (IL)-17, adiponectin, and resistin with magnetic resonance imaging-measured infrapatellar fat pad (IPFP) size and signal intensity alterations in patients with knee osteoarthritis (OA). IPFP tissues acquired from patients with knee OA can produce cytokines such as interleukin (IL)-1β, tumor necrosis factor (TNF)-α, IL-6, IL-8, IL-17, basic fibroblast growth factor, and vascular endothelial growth factor (VEGF) [8,9,10]. It can produce various adipokines such as leptin, resistin, and adiponectin [11]. Researchers in an in vitro study reported that conditioned media from cultured white adipose tissue from OA IPFP that contained leptin could induce cartilage collagen release and increase matrix metalloproteinase (MMP)-1 and MMP-13 expression in chondrocytes, and had catabolic effects on cartilage [12]
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