Serum levels of hPL, PAPP-A and PP14 in patients with early pregnancy bleeding and subchorionic hemorrhage.

Abstract

To investigate possible endocrine changes in patients with early pregnancy bleeding and subchorionic hemorrhage. Prospective study in first trimester of pregnancy comparing circulating levels of human placental lactogen (hPL), pregnancy-associated plasma protein A (PAPP-A) and endometrial secretory protein PP14 (PP14) in women with and without subchorionic hemorrhage. Sixty-nine women with early pregnancy bleeding, who in week 7-14 had a blood sample and an ultrasound study with both determination of fetal crown-rump length and a search for subchorionic hemorrhage. There was no difference between serum levels of hPL, PAPP-A and PP14 in 29 women with and 40 women without subchorionic hemorrhage, and no correlation between serum levels and the size of the hematoma. Judged from the serum levels of the studied substances there were no indications of an impaired function of the trophoblast or the decidua that could explain the development of subchorionic hemorrhage.