Abstract
The level of the total and dimeric (oligomeric) forms of soluble CD38 antigen (sCD38) has been determined by an ELISA sandwich method in serum from burned patients (n=18) and healthy volunteers ( n=25). The serum level of total sCD38 was insignificantly increased in patients at the stage of burn shock ( 135±11.4 U/ ml , mean±S.E.M.) and significantly decreased between 4 and 14 postburn days in comparison with volunteers ( 69.5±10.8 U/ ml versus 121±7.8 U/ ml , P<0.05). The serum level of soluble dimeric CD38 in burned patients was statistically lower than normal during all periods of observation (45.3±8.8 and 130±6.2 U/ ml , respectively, P<0.01). The relative number of CD38 + lymphocytes was increased during the period of shock in comparison with healthy volunteers (21±1.6% versus 13±1.1%, P<0.05). There were no correlations between number CD38 + lymphocytes and total sCD38 or dimeric sCD38 serum levels. These data suggest that the mCD38 expression and serum level of total sCD38 are a markers the early postburn lymphocytes activation. The decrease of dimeric sCD38 level can reflect its dissociation to monomeric form in burned patients.
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