Abstract
© 2012 The Authors. doi: 10.2340/00015555-1270 Journal Compilation © 2012 Acta Dermato-Venereologica. ISSN 0001-5555 Sezary syndrome is an erythrodermic cutaneous T-cell lymphoma with haematological evidence of leukemic involvement, which is typically characterized by a monoclonal proliferation of atypical CD4+CD45RO+ lymphocytes (Sezary cells). We report here a case of CD8+ Sezary syndrome that was treated successfully with methotrexate. Sezary cells were CD3+, CD4–, CD8+, CD45RO+. They also expressed CC chemokine receptor 4 and 10, but not CXC chemokine receptor 3. The number of Sezary cells and serum levels of soluble IL-2 receptor were positively correlated with serum levels of CC chemokine ligand 17, 22 and 27, whereas they were negatively correlated with serum levels of CXC chemokine ligand 10.
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