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Abstract
The serum concentrations of vitamins A (retinol), C (ascorbic acid) and E (alpha-tocopherol) of paediatric- age group were determined in sicklers and non-sicklers within the Sokoto metropolis. The levels of the antioxidant vitamins were found to be significantly lower (p < 0.001) in the sickler group when compared to that in non-sicklers. In all cases the concentrations of the antioxidant vitamins were significantly depressed in children with sickle-cell anaemia. The depletion in the levels of the three-antioxidant vitamins may probably account for some of the observed clinical manifestations of sickle-cell anaemia. This shall be the subject of our future investigation(s). Key Words: Sicklers, Non- sicklers, Serum Vitamin A, Serum Vitamin C, Serum Vitamin E. Sahel Med. J. Vol.6(2) 2003: 53-57
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