Abstract
Abstract. The levels of alpha-1 microglobulin (α1m) and beta-2 microglobulin (β2m) in serum were estimated in 77 bone marrow transplant recipients. In comparison to pretransplant levels, the highest levels of α1m and β2m were found during impairment of renal function, i. e., during cyclosporin-induced nephrotoxicity and during treatment with other nephrotoxic drugs (P< 0.001). The α1m levels were less elevated during infections and acute graft-versus-host disease (P < 0.01), while β2m levels were markedly elevated during the same conditions (P < 0.001). The linear correlations between serum creatinine and α1m and creatinine and β2m were r= 0.7 and 0.8, respectively (P < 0.001). The overall correlation between α1m and β2m was 0.4 (P< 0.001). It is concluded that α1m might be a complement to serum creatinine levels in monitoring renal function after bone marrow transplantation.
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