SERUM LEVEL OF TRACE ELEMENTS IN PANCREATIC DUCTAL ADENOCARCINOMA

Abstract

Abstract INTRODUCTION Trace elements named copper (Cu), selenium (Se) and zinc (Zn) could play a role in the development of malignancy since they act as cofactors of antioxidant enzymes. The aim was to evaluate the alterations in the serum levels of Cu, Se and Zn in patients with pancreatic ductal adenocarcinoma (PDAC), by analyzing portal and arterial blood, collected before (pre) and after (post) tumor resection. MATERIAL AND METHODS The study was carried out between September 18-May 19 with 27 resected PDAC patients. The portal and arterial blood samples collected during surgery were immediately sent to the Biochemistry laboratory, where they were stored at -80 °C until processed by mass spectrometry (ICP-MS, 7700x, Agilent). RESULTS Blood was not diluted during surgery (similar hematocrit). There was a significant positive correlation between arterial and portal serum levels (Spearman coefficient). CONCLUSIONS The concentrations of the trace elements are significantly lower after pancreatic resection. The good correlation between arterial and portal serum levels suggests that portal blood collection is unnecessary. Grants: New diagnostic strategies for early detection of pancreatic ductal adenocarcinoma (DIAGNOPANC). Ministry for Science and Innovation, 2018. C. Seijo Fernandez, Servicio de Anestesia, Hospital Universitario Central de Asturias. A. Montes Llaneza, Unidad Enfermería Quirófano, Hospital Universitario Central de Asturias. E. Castro Celeiro, Unidad Enfermería Quirófano, Hospital Universitario Central de Asturias. L. Barneo Serra, Servicio de Cirugía, Hospital Universitario Central de Asturias.