Abstract
Background: Polycystic ovary syndrome (PCOS) is a complex endocrine disorder in women of reproductive age and a major cause of infertility. Anti- Mullerian Hormone (AMH), a valid marker of ovarian function, is used for the diagnosis of PCOS. The aim of this study is to assess the serum level of total antioxidant status (TAS) and malondialdehyde (MDA) in the premenopausal women with PCOS. 
 Methods: A cross-sectional analytical study was conducted at Padmashree Diagnostics, Department of Gynecology, India from April 2016 to March 2017. Census method was used to select the samples. The oxidative stress was measured by measuring the level of TAS and MDA. The data was recorded in structured proforma and and enter in SPSS version 16.0. The data were expressed in frequency, percentage, mean and standard deviation and the results obtained were analyzed using pearson’s correlation and student’s t-test. The p-value less than 0.05 was taken as statistically significant.
 Results: The measured serum AMH level among the patients with PCOS was within normal range in 67.5% (27) and above normal range in 32.5% (13). The serum TAS level in normal AMH group was 814.0 + 291 µMol/L and in above normal range group was 720 + 240 µMol/L, (p <0.001). Similarly, the serum level of MDA in normal AMH group was 6.64 + 0.21 µMol/L, and in above normal range group was 8.78 + 0.22 µMol/L (p = 0.01). The measured level of AMH was significantly associated with the increased level of MDA (p<0.001) and decreased level of TAS (p<0.001). The measured MDA level in high AMH group did show statistically significant than the normal AMH group.
 Conclusions: Serum level of TAS and MDA along with AMH are valuable diagnostic biomarker for the diagnosis of PCOS in the resource poor settings where ultrasound facility is unavailable.
Highlights
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5-10% of female in their reproductive age.[1,2] It is the leading cause of ovulatory dysfunction causing female infertility worldwide.[1,3] Researches showed that infertility in female is mainly hormonal.[4]
During the one year of the study period, a total of 1295 patients were visited in the OPD and 230 were with PCOS
Out of the 40 patients, 67.5% (n=27) patients were with normal antimullerian hormone (AMH) level and 32.5% (n=13) were with high AMH level (Figure 1)
Summary
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder affecting 5-10% of female in their reproductive age.[1,2] It is the leading cause of ovulatory dysfunction causing female infertility worldwide.[1,3] Researches showed that infertility in female is mainly hormonal.[4] Ovary as an endocrine gland produces various hormones like estrogen, progesterone, antimullerian hormone (AMH) and little amount of androgen. The women with high level of AMH who dont have polycystic ovaries are more fertile.[7] The increase in the level of AMH has been involved in the pathogenesis of PCOS. Studies found that polycystic ovaries comprise a higher number of preantral and small antral follicles, indicating arrest of follicular development at the stage when AMH production is greatest.[8,9]
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