Abstract
Mast cells can influence tumor progression via different pathways and increased mast cell density has been demonstrated in oral squamous cell carcinoma (OSCC). It has been shown that the serum tryptase level is elevated with some malignant tumours and may thus be a useful parameter. However, there are no data available about OSCC. The main aim of this study was the evaluation of mast cell tryptase (MCT) level in OSCC patient serum. In this cross-sectional, analytic study, the circulating levels of MCT were assessed in sera of 55 OSCC patients and 34 healthy individuals with ELISA technique. The serum MCT level in OSCC patients was 12-14 ng/ml, which was not significantly higher than the healthy control group. While the serum level of MCT was higher with larger tumours, there was no apparent correlation with clinico-pathological features such as patient age, gender, tumor location, stage, nodal status, distant metastasis, histological grade and smoking. Our findings showed that despite the results obtained from studies of other malignant tumors, serum level of MCT in OSCC patients could not be a credited as a reliable indicator of the presence or progression of tumours.
Highlights
Squamous cell carcinoma (SCC) is the most common malignancy in the oral cavity
Our findings showed that despite the results obtained from studies of other malignant tumors, serum level of mast cell tryptase (MCT) in oral squamous cell carcinoma (OSCC) patients could not be a credited as a reliable indicator of the presence or progression of tumours
The mean of serum level of MCT was 12±14 ng/ ml in the OSCC group and it was 8.5±9.1 ng/ ml in the control group. (Table 2) Mann-Whitney test did not show any significant difference between two study groups
Summary
Squamous cell carcinoma (SCC) is the most common malignancy in the oral cavity. Despite the increasing knowledge and developing diagnostic and therapeutic methods, the survival rate of patients is low (Messadi et al, 2009). Inflammatory cells are present in the tumor stroma and can affect tumor development and growth (Ribatti and Crenellate, 2009) Among these immune cells, the roles of mast cells have been demonstrated in various biologic processes in the many tumors (Artuc et al, 2002; Fukushima et al, 2006; Ribatti and Crivellato, 2009). The main aim of this study was the evaluation of mast cell tryptase (MCT) level in OSCC patient serum. Results: The serum MCT level in OSCC patients was 12-14 ng/ml, which was not significantly higher than the healthy control group. Conclusions: Our findings showed that despite the results obtained from studies of other malignant tumors, serum level of MCT in OSCC patients could not be a credited as a reliable indicator of the presence or progression of tumours
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
