Abstract
1. 1. The blood concentration of haloperidol was determined in schizophrenic patients according to the three different schedules by the recently developed radioimmunoassay. 2. 2. There exists a significant positive correlation between the blood concentration and the daily dose per kg of body weight of haloperidol. 3. 3. A certain relationship is present between the blood concentration and the development of extrapyramidal symptoms (EPS). 4. 4. The combined use of antiparkinsonian drugs failed to depress the blood level of haloperidol. 5. 5. The blood concentration of haloperidol varied more widely and required much more time in attaining a steady state after administration in a single dose than after administration in divided doses.
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