Abstract
Crude coal tar (CCT) contains polycyclic aromatic hydrocarbons (PAHs). Benzo[a]pyrene (BaP) is metabolized into a highly reactive metabolite benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE) that is able to bind to DNA and creates BPDE-DNA adducts. Adducted DNA becomes immunogenic and induces immune response by production of antibodies against BPDE-DNA adducts (Ab-BPDE-DNA). Circulating Ab-BPDE-DNA was proposed as potential biomarker of genotoxic exposure to BaP (PAHs). Goeckerman therapy (GT) of psoriasis uses dermal application of CCT ointment (PAHs). In presented study (children with psoriasis treated by GT; n = 19) the therapy significantly increased the level of Ab-BPDE-DNA (EI = 0.29/0.19-0.34 vs. 0.31/0.25-0.40; median/lower-upper quartile; p < 0.01). The results support the idea of Ab-BPDE-DNA level as a possible tentative indicator of exposure, effects and susceptibility of the organism to the exposure of BaP (PAHs).
Highlights
Psoriasis is a multifactorial, chronic inflammatory skin disease, which often breaks out during childhood
In the group of children with psoriasis, dermatologically exposed to coal tar we evaluated the efficacy of the therapy and observed the level of Ab-BPDEDNA
Serum antibodies against BPDE-DNA adducts in children
Summary
Chronic inflammatory skin disease, which often breaks out during childhood. KEYWORDS polycyclic aromatic hydrocarbons; coal tar; BPDE-DNA adducts; antibodies; psoriasis; goeckerman therapy; children Increased levels of BPDE adducts indicate recent genotoxic exposure to BaP [5].
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