Abstract
Background Patients with moderate to severe forms of psoriasis have been found to be at a greater risk of developing comorbidities such as metabolic syndrome and vascular disorders. White adipose tissue is a known source of adipokines and cytokines that can mediate the development of insulin resistance, endothelial dysfunction, and atherosclerosis. The interaction between adipocytokines [such as leptin and retinol-binding protein 4 (RBP4)] and chronic skin and systemic inflammation in psoriasis can be bidirectional. Th1 and Th17 lymphocyte activation in psoriasis is a shared pathway with adipokine activation. Aim Evaluation of serum leptin, RBP4, the lipid profile, and carotid - intima media thickness (CIMT) levels in psoriatic patients as indicators of subclinical atherosclerosis. Patients and methods This study included 45 patients with psoriasis vulgaris compared with 45 age-matched and sex-matched healthy individuals as a control group. Results A highly significant difference was found in the mean leptin (P Conclusion Psoriatic patients must be advised to assess their lipid profile, serum leptin, and intima - media thickness routinely in order to predict early cardiovascular morbidity and mortality.
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