Serum Legumain Is Associated with Peripheral Artery Disease in Patients with Type 2 Diabetes.

Wen Wei,Yan Tong,Hangju Chen,Jushun Zhang,Rong Huang,Mei Tu,Wenrui Zhang,Shujin Chen,Jin Cai,Xiuping Qiu,Jianqing Huang,Ryan T Crews

doi:10.1155/2021/5651469

Abstract

Background Legumain is related to carotid atherosclerotic plaques and may be a new biomarker of carotid atherosclerosis. However, the association between legumain and peripheral artery disease (PAD) of lower extremity has been less studied. This study is aimed at exploring the potential link between legumain and PAD in patients with type 2 diabetes mellitus (T2DM). Methods A cross-sectional study was conducted on 483 hospitalized T2DM patients. The serum legumain level was measured by a sandwich enzyme-linked immunosorbent assay. PAD was evaluated by color Doppler sonography. The association between legumain and PAD was tested by logistic regression. The predictive power of legumain for PAD was evaluated with the receiver-operating-characteristic (ROC) curve. Results Overall, 201 (41.6%) patients suffered from PAD. Patients with PAD had significantly higher serum legumain level than those without PAD [11.9 (6.3, 17.9) μg/L vs. 7.6 (3.2, 14.2) μg/L, p < 0.001]. Logistic regression showed that a higher serum legumain level was independently associated with a greater risk of PAD in T2DM patients [adjusted odds ratio (aOR): 1.03; 95% confidence interval (CI): 1.01-1.06]. The area under the ROC curve was 0.634 (95% CI, 0.585 to 0.684). Conclusion High serum legumain level was significantly correlated with an increased risk of PAD in T2DM patients.

Highlights

Peripheral artery disease (PAD) of the lower extremity is one of the common macrovascular complications of diabetes and is associated with a substantial increase in the risk of foot ulceration and amputation [1, 2]
In this study, we aim to evaluate the association between serum legumain and peripheral artery disease (PAD) and whether serum legumain could be used as a predictor of PAD in patients with type 2 diabetes mellitus (T2DM)
The results demonstrated that patients with PAD showed a higher serum legumain level than those without, and the prevalence of PAD increased with the increase of the serum legumain level

Summary

Introduction

Peripheral artery disease (PAD) of the lower extremity is one of the common macrovascular complications of diabetes and is associated with a substantial increase in the risk of foot ulceration and amputation [1, 2]. No study has evaluated the serum legumain level in patients with PAD of the lower extremity. The association between legumain and peripheral artery disease (PAD) of lower extremity has been less studied. This study is aimed at exploring the potential link between legumain and PAD in patients with type 2 diabetes mellitus (T2DM). Logistic regression showed that a higher serum legumain level was independently associated with a greater risk of PAD in T2DM patients [adjusted odds ratio (aOR): 1.03; 95% confidence interval (CI): 1.01-1.06]. High serum legumain level was significantly correlated with an increased risk of PAD in T2DM patients

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Methods

Conclusion