Abstract
Granting the association of lactates with mortality has been largely documented in critically ill patients with sepsis, its association with the development of acute kidney injury (AKI) in this set...
Highlights
The primary cause of acute kidney injury (AKI) in intensive care units (ICU) is sepsis
We cross-examined data from a retrospective study in which we studied a cohort of critically ill patients admitted with sepsis to the ICU and in which the primary objective was to compare the diagnostic sensitivity and prognostic ability of the standard classifications for AKI, namely the ‘Risk, Injury, Failure, Loss of kidney function, End-stage kidney disease’ (RIFLE), Acute Kidney Injury Network (AKIN) and Kidney Disease: Improving Global Outcomes (KDIGO) classifications (Pereira et al, 2016)
This study is retrospective in nature and inclusive of all patients with sepsis admitted between January 2008 and December 2014 to the Division of Intensive Medicine of the Centro Hospitalar Lisboa Norte (Lisbon, Portugal), an academic and referral center serving a population of 3,000,000 inhabitants
Summary
The primary cause of acute kidney injury (AKI) in intensive care units (ICU) is sepsis. Serum lactate has been widely considered as an important biomarker for the evaluation of hemodynamic status in the critically ill patient. Since lactate is a sensitive biomarker of global and regional hypoperfusion, lactate can be used as a marker of ongoing hypoperfusion that may contribute to continuing development of AKI (Zhang & Ni, 2015). Despite the fact that the deleterious impact of raised serum lactates on mortality has been broadly reported in critically ill septic patients (Moskowitz et al, 2016; Singer et al, 2016), the association of serum lactates with the development of AKI in sepsis is still not well defined
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