Abstract
Background: In this study, we investigated the relationship between serum lactate dehydrogenase (LDH) level and disease progression and prognosis of patients with COVID-19.Methods: We retrospectively reviewed the information of 1,751 patients with COVID-19 from Leishenshan Hospital in Wuhan, China. Univariate and multivariate Cox regression analyses as well as Logistics regression analyses, and Kaplan-Meier curves were used to determine the association between LDH levels and the prognosis of COVID-19 patients.Results: LDH was an independent risk factor for in-hospital death no matter it was taken as classified variable and continuous variable (all P = 0.001) but not for severe or critical illness status. The Kaplan-Meier curves for LDH level showed that an elevated level of LDH was associated with in-hospital death.Conclusions: In patients with COVID-19, the increased LDH level is associated with a higher risk of negative clinical prognosis and higher mortality. This will provide a reference for clinicians and researchers to understand, diagnose, and treat patients with COVID-19. Further prospective studies with larger sample sizes are needed to verify these findings.
Highlights
The world is currently experiencing a major coronavirus disease 2019 (COVID-19) pandemic [1–3]
We investigated the effect of serum Lactate dehydrogenase (LDH) levels on the disease progression and prognosis of patients with COVID-19
Severe and critical cases account for a major part of patients with elevated LDH level no matter on LDH normal or decreased group (n = 1,696)
Summary
The world is currently experiencing a major coronavirus disease 2019 (COVID-19) pandemic [1–3]. COVID-19 can cause severe illness, the case fatality rate is relatively low [4]. As of 22 April 2020, more than 2,500,000 cases were reported worldwide, with more than 170,000 deaths. Leshenshan Hospital is hosted by Zhongnan Hospital and is a temporary, specialized 1,600-bed hospital designated for the treatment of patients with COVID-19. From February 8, 2020 to LDH as COVID-19 Prognostic Factor. April 15, 2020, 1,880 patients with confirmed COVID-19 were admitted. Elevated LDH levels have been shown to be associated with more severe disease and increased mortality in multiple diseases [5–7]. We investigated the relationship between serum lactate dehydrogenase (LDH) level and disease progression and prognosis of patients with COVID-19
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
