Serum KIM-1 and Cyctatin levels as predictors of acute kidney injury in asphyxiated neonates

Abstract

Introduction: Asphyxia may lead to serious complications among them acute kidney injury (AKI) is the most common. Early diagnosis of AKI can help prevent impaired acid-base, fluid and electrolytes balance that may lead to life-threatening complications. The current study has aimed to assess efficacy of KIM-1 and Cystatin-C in early diagnosis of AKI among asphyxiate neonates. Methods: This is a case-control study conducted on 45 asphyxiate neonates, which 24 were in the control group and 23 in the case group.Creatinine, KIM-1 and Cystatine-C were measured for participants within 8- and 4 days after birth and compared between cases and controls. Results: The mean level of Cr-Standardized KIM1 8 hours and 4 days after birth was significantly higher in case group compared to the control (p-value 0.67 ng/ml allows to predict kidney failure in newborns with 57.1‌% sensitivity and 86.4‌% specificity. Conclusion: Our study showed that high-specificity Kim-1 is a good biomarker for early detection of acute renal failure in asphyxiated infants, but similar expectations of cystatin cannot be expected for at least the first 8 hours after birth.