Abstract
The serum iron concentration and Total Iron Binding Capacity (TIBC) status of 24 patients of oral squamous cell carcinoma (OSCC) were compared with the findings of 13 healthy subjects. OSCC was found to have association with low serum iron level. More patients were found to be with significantly lower iron content in serum (p<0.05). But no association between serum TIBC and increased risk of cancer was found (p>0.05). Irrespective of age, sex, smoking and betel nut chewing habit of subjects, low serum iron level significantly increase the risk of oral malignancy.
Highlights
Oral cancer is becoming a problem for all over the world and the incidence is high in the least developed or undeveloped countries like Bangladesh (WHO, 1984; Chiba et al, 1998; Watkinson, 2001; Goselin, 2006)
The serum was preserved in 1.5 mL appendrof tube in deep freeze until measuring iron and total iron binding capacity (TIBC)
Researches across the globe endeavored to elucidate possible relationship of trace elements with the risk of cancer in humans. Several of their ventures uncovered the peril related with several familiar trace elements, with zinc, copper, iron, TIBC and ferritin as well
Summary
Oral cancer is becoming a problem for all over the world and the incidence is high in the least developed or undeveloped countries like Bangladesh (WHO, 1984; Chiba et al, 1998; Watkinson, 2001; Goselin, 2006). In Bangladesh the number of new cancer cases per year is about 200,000 of which oral cancer is about 20% (Shaheed et al, 1995). Due to some geographic distribution and socioeconomic condition, the rate of oral cancer is high in our country than the developed countries. The common site of oral cancer differs due to some habit (Hasan and Molla, 1997; Talukder and Molla, 1997). The etiology of oral cancer is a complex, multi-factorial, ill-defined and incomplete concept. Risk factor includes betel nut, chewing tobacco, smoking, age, familial or genetic predisposition, poor oral hygiene and chronic irritation, nutritional status, alcohol, exposure to industrial products or heavy metals, viruses, ionizing radiation, oral candidiasis, etc (Goselin 2006; Binnie et al, 1983)
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