Abstract
Recent studies have shown that low-grade inflammation plays an important role in the development of diabetes vascular complications (1). Interleukin-18 (IL-18) is well known to play a key role in various inflammatory and autoimmune diseases (2). IL-18 produces proinflammatory cytokines and upregulates various adhesion molecule expression (3,4). These processes could lead to the development of diabetes vascular complications including atherosclerosis. Indeed, serum IL-18 levels can be a strong predictor of death in patients with cardiovascular diseases (5,6) and is associated with nephropathy and atherosclerosis in type 2 diabetic patients (7). It was also reported (8) that serum IL-18 levels were increased during the early developing stage of type 1 diabetes, but we cannot exclude the possibility that these results were simply influenced by inflammation at the onset of type 1 diabetes. In this study, we examined serum IL-18 levels in the chronic stage of type 1 diabetes and the possible association between serum IL-18 and various soluble adhesion molecule levels. A total of 77 Japanese type 1 diabetic patients (25 men and 52 women, mean ± SD age 23.3 ± 4.4 years, duration of diabetes 13.2 ± …
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
