Serum Interleukin-15 and its relationship with adiposity Indices before and after short-term endurance exercise.

Mozaffer Rahim Hingorjo,Masood Anwar Qureshi,Sitwat Zehra,Saima Saleem

doi:10.12669/pjms.345.15516

Abstract

Objective:The myokine interleukin-15 (IL-15) is capable of modifying the metabolism of both skeletal and adipose tissue. This study compares the change in serum levels of IL-15 in obese and non-obese after a single session of submaximal exercise.Methods:A cross-sectional study was carried out at Jinnah Medical and Dental College, Karachi, during Aug-Dec 2015, comprising of 133 medical students (aged 17-24 years). Cardiorespiratory fitness was evaluated by Queen’s College Step Test. Blood was obtained both before and just after exercise and serum levels of IL-15 determined by enzyme-linked immunosorbent assay.Results:Mean serum level of IL-15 was 3.64±1.59 pg/mL. Higher levels of IL-15 were seen in lean subjects compared to overweight/obese, both before and after three minutes of exercise (all Ptrend<.001). The percent increase in IL-15 upon exercise was 12.7% higher in lean. Significant negative association was seen between interleukin-15 and adiposity, especially visceral fat (r = –.288, p=.001).Conclusion:Interleukin-15 correlates negatively with adiposity indices, especially visceral fat. With the proven benefit of IL-15 in terms of adipose tissue stores and skeletal muscle mitochondrial biogenesis, endurance exercises, even of short duration, may possess therapeutic potential towards producing a healthier body.

Highlights

IntroductionFirst discovered in 1994 as an immune modulating agent,[1] it is considered anabolic for proteins, enhancing myogenesis and Correspondence: April 28, 2018 May 12, 2018 August 20, 2018 August 25, 2018 providing protection against protein degradation.[2] The release of IL-15 upon exercise increases glucose uptake by translocating GLUT4 to the plasma membrane.[3] Due to its anabolic and muscle building effects, it has been called as the ‘Arnold cytokine’ after the body builder Arnold Schwartzenneger.[4] The level of IL-15 depends upon the type, intensity and duration of exercise
Interleukin-15 is a myokine released from exercising muscles
This study compared the change in serum IL15 level after a single session of submaximal exercise in obese and non-obese individuals

Summary

Introduction

First discovered in 1994 as an immune modulating agent,[1] it is considered anabolic for proteins, enhancing myogenesis and Correspondence: April 28, 2018 May 12, 2018 August 20, 2018 August 25, 2018 providing protection against protein degradation.[2] The release of IL-15 upon exercise increases glucose uptake by translocating GLUT4 to the plasma membrane.[3] Due to its anabolic and muscle building effects, it has been called as the ‘Arnold cytokine’ after the body builder Arnold Schwartzenneger.[4] The level of IL-15 depends upon the type, intensity and duration of exercise. Higher levels of IL-15 have been observed after both resistance and endurance training. No change in plasma level of IL15 was observed after acute exercise lasting 3 hours or less.[5]

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Discussion

Conclusion