Abstract
To the Editor. —In most cases the etiology of nongranulomatous anterior uveitis is obscure. Both infectious and imunological hypersensitivity mechanisms have been postulated. A heretofore undetected virus often is contemplated as the infectious agent. Interferon is a protein produced by virusinfected cells, which acts intracellularly to prevent replication of viruses. 1 It can be measured in the serum of patients within 24 hours after viremia 2 and usually persists in the serum for about three to five days . Serum interferon has been detected during the early clinical course of several viral infections. 4-7 Thus, if uveitis were virus-mediated, it might be possible to measure serum interferon levels in patients with acute nongranulomatous anterior uveitis. I have studied the serum interferon levels of two patients with typical acute, monocular, nongranulomatous anterior uveitis of unknown cause. Neither patient had a history of previous eye disease. Interferon was measured using a modification of
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