Abstract
Objective: To investigate the association between serum concentration of insulin-like growth factor (IGF) and the risk of pancreatic cancer (PaC). Methods: We identified eligible studies in Medline and EMBASE databases (no reference trials from 2014 to 2016) in addition to the reference lists of original studies and review articles on this topic. A summary of relative risks with 95% confidence intervals (CI) was calculated using a random-effects model. The heterogeneity between studies was assessed using Cochran Q and I2 statistics. Results: Ten studies (seven nested case-control studies and three retrospective case-control studies) were selected as they met our inclusion criteria in this meta-analysis. All these studies were published between 1997 and 2013. The current data suggested that serum concentrations of IGF-I, IGF-II and insulin-like growth factor binding protein-3 (IGFBP-3)in addition to the IGF-I/IGFBP-3 ratio were not associated with an increased risk of PaC (Summary relative risks (SRRs) = 0.92, 95% CI: 0.67–1.16 for IGF-I; SRRs = 0.84, 95% CI: 0.54–1.15 for IGF-II; SRRs = 0.93, 95% CI: 0.69–1.17 for IGFBP-3; SRRs = 0.97, 95% CI: 0.71–1.23 for IGF-I/IGFBP-3 ratio). There was no publication bias in the present meta-analysis. Conclusion: Serum concentrations of IGF-I, IGF-II, IGFBP-1 and IGFBP-3 as well as the IGF-I/IGFBP-3 ratio were not associated with increased risk of PaC.
Highlights
Pancreatic cancer (PaC) ranks as the fourth most common cause of death from cancer in both men and women in the United States [1]
We evaluated the role of several potential sources of heterogeneity by sub-group analyses according to adjustments for confounding variables: alcohol consumption, smoking and diabetes mellitus (DM)
A total of 294 citations were obtained for review of the title and abstract
Summary
Pancreatic cancer (PaC) ranks as the fourth most common cause of death from cancer in both men and women in the United States [1]. Despite decades of effort by clinicians and scientists, the five-year survival rate remains poor, as it has only reached a maximum of 5%. The incidence and mortality rates of PaC in the United States have remained stable over the past two decades [2]. The incidence rate of PaC in males from China rose in the period from 2000 to 2011 [3]. Radical resection is the only potentially curative therapy. As it is difficult to diagnose in its early stage, approximately 80% of patients cannot receive surgical resection. The five-year survival rate is about 20% after resection. Patients suffering from local, advanced, unresectable or metastatic disease can undergo chemotherapy or chemo-radiotherapy if these patients have a good performance status
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