Abstract
Background The clinical management of bacterial infection computes factors related to bacteria (e.g., resistance profile [1]), antibiotics (e.g., activity spectrum, distribution volume, etc.), host characteristics (e.g., vascularization of the infected tissue, effectiveness of host defenses, etc.), as well as pharmacokinetic (PK) parameters [2]. The serum inhibitory (SIT) and bactericidal titers (SBT) are laboratory tests that simulate the interactions between antibiotics and bacteria in the human body milieu.
Highlights
The clinical management of bacterial infection computes factors related to bacteria, antibiotics, host characteristics, as well as pharmacokinetic (PK) parameters [2]
The strains had been isolated from blood cultures (49.4%), cutaneous wounds (23.6%), tracheal aspirate (13.5%) and urine samples (7.9%)
serum inhibitory (SIT) ranged from 1/2 (12.4%) to 1/512 (5.6%), but only in 20 cases (22.4%) the titers were in the therapeutic comfort range of 1/64 to 1/512
Summary
The clinical management of bacterial infection computes factors related to bacteria (e.g., resistance profile [1]), antibiotics (e.g., activity spectrum, distribution volume, etc.), host characteristics (e.g., vascularization of the infected tissue, effectiveness of host defenses, etc.), as well as pharmacokinetic (PK) parameters [2]. The serum inhibitory (SIT) and bactericidal titers (SBT) are laboratory tests that simulate the interactions between antibiotics and bacteria in the human body milieu
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