Abstract
Meeting abstracts Treatment with ipilimumab improves overall survival (OS) in patients with metastatic melanoma. Because ipilimumab targets T lymphocytes and not the tumor itself, efficacy may be uniquely sensitive to immunomodulatory factors present at the time of treatment. We analyzed serum
Highlights
Treatment with ipilimumab improves overall survival (OS) in patients with metastatic melanoma
After controlling for baseline covariates, elevated CXCL11 and soluble MHC class I polypeptide-related chain A (sMICA) were associated with poor OS in ipilimumab-treated patients (log10 CXCL11: hazard ratio (HR), 1.88; 95% CI, 1.14 to 3.12; P = 0.014; and log10 sMICA quadratic effect P = 0.066; sMICA (≥247 vs < 247): HR, 1.75; 95% CI, 1.02 to 3.01) but not in gp100-treated patients
Multivariate analysis of an independent ipilimumab-treated cohort confirmed the association between log10 CXCL11 and OS (HR, 3.18; 95% CI 1.13 to 8.95; P = 0.029), while sMICA was less strongly associated with OS (log10 sMICA quadratic effect P = 0.16; sMICA (≥247 vs < 247): HR, 1.48; 95% CI, 0.67 to 3.27)
Summary
Yoshinobu Koguchi1*, Helena Hoen, Shelly Bambina, Michael Rynning, Richard Fuerstenberg, Zipei Feng, Bernard Fox, Carlo Bifulco, Brendan D Curti, Walter Urba, Christina Milburn, Alan J Korman, Keith S Bahjat. From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. From 30th Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2015) National Harbor, MD, USA. 4-8 November 2015
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