Abstract
Objectives. To assess serum interleukin-6 (IL-6) and interleukin-23 (IL-23) and their correlation with angiogenic cytokines and disease activity in ankylosing spondylitis (AS), psoriatic arthritis (PsA), and SAPHO syndrome. Patients and Methods. We studied 152 spondyloarthritis (SpA) patients: 69 PsA, 61 AS, 22 SAPHO, and 29 controls. We recorded age, sex, disease duration, and treatment. We assessed BASDAI, VAS, and PASI scores. Serum IL-6, IL-23, VEGF, EGF, FGFb, and FGFa levels were determined using ELISA. We estimated ESR and CRP. Results. Serum IL-6 and IL-23 levels were higher in SpA than in control (P < 0.00001 and P = 0.0004, resp.). There was a positive correlation between serum IL-6 and CRP in AS (P = 0.000001), PsA (P = 0.000001), and SAPHO (P = 0.0003) patients. There was a positive correlation between serum IL-6 and ESR in AS (P = 0.000001), PsA (P = 0.002), and SAPHO (P = 0.02) patients. There was no correlation of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines in SpA. Conclusions. Serum IL-6 but not serum IL-23 correlated with ESR and CRP in SpA. No correlation was found of serum IL-6 and IL-23 with VAS, BASDAI, and angiogenic cytokines.
Highlights
Spondyloarthropathies (SpA) are a group of chronic, inflammatory, immune-mediated disorders of the axial and peripheral joints
We evaluated the relationship between serum levels of IL-6 and IL-23 and activity of ankylosing spondylitis (AS), psoriatic arthritis (PsA), and SAPHO syndrome
Elevated levels of IL-6 have been described in patients with PsA compared with patients with psoriasis [19]
Summary
Spondyloarthropathies (SpA) are a group of chronic, inflammatory, immune-mediated disorders of the axial and peripheral joints. This group encompasses ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, enteropathic arthritis, and undifferentiated seronegative arthritis. The aetiology of SpA is unknown, but some cytokines such as interleukin-6 (IL6) and interleukin-23 (IL-23) are considered to be associated with the pathogenesis of these disorders [1,2,3,4,5,6,7]. We found that few reports assessed serum levels of IL-23 in small groups of AS and PsA patients [8, 9]. There were no data in the available literature concerning serum levels of IL-6 and IL-23 in SAPHO syndrome
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