Abstract
Objective:To investigate the serum levels of Interleukin (IL)-17 and eotaxin levels and the relationship between serum IL-17, eotaxin and pulmonary function in asthmatic patients with allergic rhinitis.Methods:Serum IL-17 and eotaxin levels in asthmatic patients with allergic rhinitis during attacking and remission and in healthy control subjects were measured using enzyme-linked immunosorbent assay (ELISA) kits. Then we studied the correlation between the serum IL-17, eotaxin levels and pulmonary function in patients.Results:Serum IL-17 and eotaxin levels were significantly elevated in patients during asthma attack and remission compared with healthy control subjects. These levels in patients during asthma attack were much higher than those during remission. Furthermore, serum IL-17 and eotaxin levels were negatively correlated with pulmonary function in asthmatic patients with allergic rhinitis, respectively.Conclusion:Our findings suggest that IL-17 and eotaxin are important factors in asthma with allergic rhinitis, and the correlation between serum IL-17, eotaxin and lung function possibly lead to improvements in the diagnosis and treatment of asthma with allergic rhinitis and related diseases.
Highlights
Asthma is a chronic inflammatory disease of airways characterized by chronic inflammation, airway hyper-reactivity, and by symptoms of coughing, wheezing and chest tightness
The present study showed significantly increased serum IL-17 and eotaxin levels in patients with and without asthma attacks compared to healthy subjects
Consistent with these, we demonstrated that elevated serum IL-17 levels were observed in patients during attacking, which were greatly decreased during remission g
Summary
Asthma is a chronic inflammatory disease of airways characterized by chronic inflammation, airway hyper-reactivity, and by symptoms of coughing, wheezing and chest tightness. Mast cells and Th2 lymphocytes are activated in the lung to generate IL-4, IL-3 and tumour necrosis factor (TNF)-α.12 These cytokines stimulate the generation of eotaxin, which acting on CC chemokine receptor 3 (CCR3) on eosinophilsthen stimulate the migration of eosinphils into the lung tissue. Recent study reported that eotaxin could activate extracellular signal regulated kinase 2 (ERK2) and p38 mitogen activated protein kinase (MAPK) to stimulate the migration of eosinphils to epithelial cells, activate, produce and release several inflammatory mediators to induce airway inflammation.[13] In addition, the elevated eotaxin levels were observed in allergicrhinitis.[14] All these above suggested that IL-17 and eotaxin play a critical role in asthma and allergic rhinitis
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