Serum IL-1β, IL-6, IL-8, and TNF-α Levels in Early Diagnosis and Management of Neonatal Sepsis

A Nese Citak Kurt,Abdullah Kurt,Ahmet Godekmerdan,A Denizmen Aygun,Erdal Yilmaz,Yasar Dogan

doi:10.1155/2007/31397

Abstract

Aim. To determine serum IL-1, IL-6, IL-8, and TNF- levels in neonatal sepsis at the time of diagnosis and after therapy, and to show the meaningful on the follow up. Methods. This prospective study was performed on newborns who were hospitalized for neonatal sepsis and who were classified as culture-proven sepsis (), as culture-negative sepsis (), and as healthy newborns (). Results. At the time of diagnosis, serum IL-1, IL-6, IL-8, and TNF- levels of culture-proven sepsis were significantly higher than those of the control groups (). At the time of diagnosis, IL-1, IL-6, IL-8, and TNF- levels of culture-proven sepsis and culture-negative sepsis were significantly higher than levels at the seventh day after antibiotic treatment. Conclusion. Serum IL-1, IL-6, IL-8, and TNF- are mediators of inflammation and can be used at the diagnosis and at the evaluation of the therapeutic efficiency in neonatal sepsis.

Highlights

IntroductionEspecially preterm, may rapidly evolve into generalized sepsis
Bacterial infection in newborns, especially preterm, may rapidly evolve into generalized sepsis
This prospective study was performed on newborns who were hospitalized for neonatal sepsis at neonatal intensive care unit (NICU)

Summary

Introduction

Especially preterm, may rapidly evolve into generalized sepsis. This condition has a gradual and subtle onset, with nonspecific symptoms that may severely compromise the infant’s clinical state if untreated and lead to life-threatening consequences. Neonatal sepsis has a fairly low incidence at birth (1–10/1000 live births) but may affect up to 16% of infants in the neonatal intensive care unit (NICU) with birth weight of 501– 1500 gm. The mortality rate is very high: 15–50% of affected infants [1]. Clinical manifestations are nonspecific and laboratory parameters such as white blood cell (WBC) count or Creactive protein (CRP) are of limited value in identifying infected newborns. Appropriate diagnosis and therapy could be delayed, worsening the prognosis of the patient [2,3,4,5,6]

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Conclusion