Abstract
Distant metastases in head and neck cancer patients almost invariably herald a poor prognosis. Five year survival rates for early stage localized head and neck cancers are over 80% but this drop to 40% where disease has spread to neck nodes, and to below 20% for patients with distant metastatic disease. A key process in this metastatic cascade is the transition of tumor cells from an adherent epithelial phenotype into a highly motile and invasive mesenchymal phenotype. We have recently demonstrated that IL-6 is a potent inducer of epithelial-mesenchymal transition (EMT) in HNSCC.
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