Serum IL-17, obesity, and metabolic risk in Mexican young adults

Celia Aradillas-García,Elizabeth Monreal-Escalante,Margarita Terán-García,Jorge Alegría-Torres,Juan Manuel Vargas-Morlaes,Diana Patricia Portales-Pérez,Sergio Rosales-Méndoza

doi:10.29105/respyn20.3-1

Abstract

BACKGROUND: Obesity and several inflammatory pathways contribute to the development of metabolic diseases. Some pro-inflammatory cytokines and other signal proteins produced in fat and liver appear to propagate inflammation systemically. IL-17 is a pro-inflammatory cytokine secreted by activated T-cells. Upon binding to its receptor, IL-17 activates a cascade of signals that include MAPK, NF-kB and other pro- inflammatory cytokines. The aim of this study was to determine if the IL-17 levels are associated with obesity and its metabolic comorbidities in young adults. METHODS: Cross-sectional study in the UP AMIGOS 2009 cohort. Anthropometric measurement and blood samples were collected. Fasting glucose, insulin, and serum lipid profile was measured by conventional methods. Serum IL-17 was determined by ELISA assay in 102 individuals with obesity and overweight also in 306 lean students (aged 18 to 26 years old. RESULTS: Higher levels of IL-17 were found in the group with obesity (34.99 pg/mL) when compared to lean subjects (26.57 pg/mL). In addition, a positive correlation between serum IL-17 and body mass index and waist circumference in the group with obesity were detected. CONCLUSIONS: Increased IL-17 levels in young individuals with obesity and overweight are associated with risk factors for developing chronic metabolic diseases

Highlights

Obesity and several inflammatory pathways contribute to the development of metabolic diseases
All variables were statistically different between cases and control group; in comparison with control group, case group showed increased values for body mass index, waist circumference, systolic and diastolic pressure, triglycerides, total cholesterol, fasting glucose, insulin and homeostasis model assessment (HOMA) index
The male sex had body mass index, waist circumference, blood pressure, triglycerides, total cholesterol and glucose with higher values than the female sex; HDL-cholesterol and IL-17 were higher in girls than in boys (P

Summary

Introduction

Obesity and several inflammatory pathways contribute to the development of metabolic diseases. Conclusions: Increased IL-17 levels in young individuals with obesity and overweight are associated with risk factors for developing chronic metabolic diseases. Obesity is a major public health problem because its prevalence is increasing rapidly in the world It is considered a chronic disease, defined as an excessive body weight due to the dysfunctional accumulation of energy reserves as fat depots, that is caused predominantly by an imbalance between energy intake and energy expenditure, the quality of the diet and macronutrients distribution are important as well as genetic factors, and physical activity (Gregor & Hotamisligil, 2011; SanCristobal, Navas-Carretero, Martínez-González, Ordovas & Martínez, 2020). Obesity is associated with increases in systemic inflammatory markers, as evidenced by studies documenting the association of body mass index (BMI) and visceral obesity with circulating levels of cytokines and acute-phase reactants (Esposito, Giugliano, Scuderi & Giugliano, 2006; Ferrante, 2007). Immune response alterations because of a low-grade inflammation are presented with a consequent increase in circulating levels of proinflammatory cytokines such as IL-6, IL-1β and TNF-α (Alexandraki et al, 2006; Balistreri, Caruso, & Candore, 2010; Hotamisligil, 2006; Skrha, 2010; Wellen & Hotamisligil, 2005)

Objectives

Methods

Results

Discussion

Conclusion